Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation

University of Zurich (UZH)

Status: Invitation-only

Conditions: Epilepsy; Movement Disorders

Treatments: Procedure: deep brain stimulation (DBS)

Study type: Observational

Funder types: Other

Identifiers

NCT01210781

DBS

Details and patient eligibility

About

Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement.

The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires.

• Trial with surgical intervention

Full description

Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement.

The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients fullfill all criteria for implantation of deep brain stimulation (DBS) electrodes
• Patients are able to give informed written consent

Exclusion criteria

• Patients do not their give informed written consent