Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients

Medical University of Vienna

Status: Completed

Conditions: Urinary Tract Infection; Abdominal Infection; Pneumonia

Study type: Observational

Funder types: Other

Identifiers

NCT01414959

Dori_MD_ICU

Details and patient eligibility

About

The investigators will measure the pharmacokinetics of doripenem in skeletal muscle, subcutaneous adipose tissue, bronchoalveolar lavage and plasma of intubated intensive care patients.

Full description

Methods: microdialysis, blood sampling, bronchoalveolar lavage

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• endotracheal intubation; pneumonia or complicated abdominal infection or complicated urinary tract infection

Exclusion criteria

• allergy to doripenem, hemodialysis