Target Therapies Resistance Molecular Profiling in Patients With Neoplastic Disease (PROFILING)

Fondazione del Piemonte per l'Oncologia

Status: Unknown

Conditions: Solid Tumors

Study type: Observational

Funder types: Other

Identifiers

NCT03347318

001-IRCC-00IIS-10

Details and patient eligibility

About

The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.

Enrollment: 2,500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with at least one of the following selected solid tumors:

• Colorectal Cancer (primary or with synchronous/metachronous liver metastases)
• Prostate Cancer
• Head & Neck Tumors
• Gastric Cancer
• Glioblastoma
• Breast Cancer
• Hepatocarcinoma
• Biliary Tract Carcinoma
• Lung Cancer (primary)
• Rare Tumors (incidence ≤ 5x10-6)
• Metastatic Sarcoma
• Metastatic Melanoma

Exclusion criteria