Targeted Α-synuclein PET Imaging in the Diagnosis of Multiple System Atrophy

Min Zhao,MD

Status: Enrolling

Conditions: Multiple System Atrophy - Parkinsonian Subtype (MSA-P); Multiple System Atrophy - Cerebellar Subtype (MSA-C)

Study type: Observational

Funder types: Other

Identifiers

NCT06890377

Rapid24408

Details and patient eligibility

About

The aim of this study was to apply the targeted α-synuclein PET study technique to investigate the pathological load and spatial distribution characteristics of α-syn in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis in MSA.

Enrollment: 90 estimated patients

Sex: All

Ages: 35 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age> 35 years old, gender is not limited;
• Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
• all patients had been ruled out of polyQ disease by genetic testing;
• Voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

• pregnancy or breastfeeding;
• contraindications to MRI examination or inability to cooperate in completing neuroimaging examination;
• previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above);
• History of alcohol or drug abuse

Trial design

90 participants in 3 patient groups

MSA-C group

Description:

Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-C type (with cerebellar ataxia as the main manifestation) mainly include progressive cerebellar ataxia and autonomic dysfunction.

MSA-P group

Description:

Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-P (multiple system atrophy-P type) mainly include autonomic dysfunction, Parkinson's syndrome and cerebellar ataxia.

healthy control group

Description:

The healthy person who age, gender and other basic conditions matched with the MSA cohort population，and voluntarily participate in this study and sign the informed consent.