Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)

The University of Texas System (UT)

Status: Completed

Conditions: Cocaine Use Disorder

Treatments: Device: Sham iTBS; Device: iTBS to dmPFC

Study type: Interventional

Funder types: Other

Identifiers

NCT05631548

HSC-MS-21-0813 (pilot study)

Details and patient eligibility

About

The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and cocaine craving in cocaine users

Enrollment: 6 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CUD diagnosis

Exclusion criteria

• moderate or severe criteria for substances other than cocaine, cannabis, or nicotine
• unstable psychiatric disorder
• medical conditions contraindicated to TMS (e.g., medical implants, history of seizure or seizure disorder, medications lowering the seizure threshold, neurological conditions, moderate-to-severe heart disease)
• pregnancy
• hairstyles incompatible with the EEG net
• head injury with loss of consciousness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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6 participants in 2 patient groups

iTBS to dmPFC, Then Sham iTBS

Experimental group

Treatment:

Device: iTBS to dmPFC

Device: Sham iTBS

Sham iTBS, Then iTBS to dmPFC

Sham Comparator group

Treatment:

Device: iTBS to dmPFC

Device: Sham iTBS