Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

University of Minnesota (UMN)

Status: Not yet enrolling

Conditions: Persistent Post Concussion Syndrome; Mild Traumatic Brain Injury

Treatments: Device: Active tDCS; Device: Sham tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT07246993

PSYCH-2025-34246

Details and patient eligibility

About

This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mild traumatic brain injury (mTBI).

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-65
• Has sustained a single mTBI 3-12 months prior to enrollment
• Meets criteria for PPCS (assessed using the CP Screen)
• Has reliable access to a smartphone

Exclusion criteria

• Inability to provide informed consent or complete study procedures
• History of moderate/severe TBI
• Significant neurological or psychiatric disorders (other than PPCS-related symptoms like mild depression/anxiety)
• Substance dependence within the last six months
• Contraindications to tDCS (e.g., implanted metal, skin lesions on scalp)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

Active tDCS + Cognitive Training

Active Comparator group

Treatment:

Device: Active tDCS

Sham tDCS + Cognitive Training

Placebo Comparator group

Treatment:

Device: Sham tDCS