Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease (MYO-MASLD)

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Not yet enrolling

Conditions: Metabolic Dysfunction-associated Steatotic Liver Disease

Treatments: Other: Moderate intensity exercise training; Other: Low intensity exercise training; Other: High-intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT06506513

ST-IR-01 MYO-MASLD

Details and patient eligibility

About

Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.

Full description

In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• confirmed MASLD at abdominal imaging
• confirmed excessive muscle lipid content at imaging
• stable weight

Exclusion criteria

• severe comorbidities including active malignancies, neuromuscular degenerative diseases
• contraindications to physical activity
• excessive alcohol consumption

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

control group

Active Comparator group

Description:

in this control group, patients will perform non-cardiovascular non-intensity training (stretching, meditation).

Treatment:

Other: Low intensity exercise training

moderate-intensity low interval training group

Active Comparator group

Description:

In this group, patients will perform moderate-intensity low interval training.

Treatment:

Other: Moderate intensity exercise training

high-intensity interval training

Active Comparator group

Description:

In this group, patients willp erform high-intensity interval training.

Treatment:

Other: High-intensity interval training