TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries

Recep Tayyip Erdogan University Training and Research Hospital

Status: Completed

Conditions: High Caries Risk; Low Caries Risk

Treatments: Genetic: high caries risk; Other: caries activity

Study type: Observational

Funder types: Other

Identifiers

NCT04066101

2016/30

Details and patient eligibility

About

The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.

Full description

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

CA6 exists in the human saliva and has a critical role of buffering, immune response and taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for umami cause perception of these tastes differently.

Enrollment: 200 patients

Sex: All

Ages: 25 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adult be between 25 and 44 years old
• subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
• same oral health, diet and socioeconomic status

Exclusion criteria

• systemic or genetic disorders
• orthodontic appliances
• pregnant women

Trial design

200 participants in 2 patient groups

high caries risk

Description:

100 adults will be allowed in the high caries risk group according to DMFT index (DMFT ≥ 14)

Treatment:

Other: caries activity

Genetic: high caries risk

low caries risk

Description:

100 adults will be allowed in the low caries risk group according to DMFT index (DMFT ≤ 5)

Treatment:

Other: caries activity

Genetic: high caries risk