TASK-002: Bioequivalence of Bedaquiline 400mg Administered in Crushed Form Compared to Tablet Form in Healthy Male and Female Adults Under Fed Conditions (BDQ Crush Study)

International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Status and phase

Completed

Early Phase 1

Conditions

Tuberculosis

Treatments

Drug: bedaquiline

Study type

Interventional

Funder types

NETWORK

Other

NIH

Identifiers

NCT03032367

TASK-002

Details and patient eligibility

About

This is a randomized, open-label, cross-over study comparing the bioequivalence of bedaquiline administered in whole tablet form versus bedaquiline administered in crushed (experimental) form in healthy adult volunteers.

Full description

This is a randomized, open-label, cross-over, bioequivalence study with two single treatment periods, separated by a 14-day wash-out period, conducted among 24 healthy adult males and females, who receive 400mg (4 x 100mg) bedaquiline orally in one of two sequences: either first in whole tablet form and second in crushed (experimental) form, or vice versa under fed conditions. The bioequivalence evaluation will be based on primary pharmacokinetic (pk) parameters affecting the extent of absorption, i.e., the bioavailability. If bioequivalence is not shown, the knowledge about the differences in bioavailability between whole and crushed tablets will be used for assessing the need of dose adjustment in children receiving the crushed form.

Enrollment

24 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Written informed consent, including HIV testing
Male or female between 18 and 55 years of age inclusive
Body weight (in light clothing and with no shoes) between 40 and 90 kg, inclusive
In the opinion of the investigator, able to comply with the requirements of the protocol e.g. able to attend all visits for PK analysis
Be of non-childbearing potential or using effective methods of birth control

Exclusion criteria

Known or suspected hypersensitivity or intolerance to bedaquiline or any other constituents of the study drug, i.e. lactose
A history or clinical evidence of any clinically significant cardiac condition including but not limited to congenital long QT syndrome, Torsades de Pointes, bradyarrhythmias
Uncontrolled cardiac dysrhythmias
Severe hepatic impairment (Child Pugh C)
History, symptoms or signs of heart failure
History, symptoms or signs of hypothyroidism, whether currently controlled or uncontrolled
Any other serious uncontrolled medical condition or clinically significant abnormality, which, in the opinion of the investigator, might compromise the safety of the subject or which might interfere with the study.
Evidence of clinically significant (as judged by the investigator), metabolic, gastrointestinal, cardiovascular, musculoskeletal, ophthalmological, pulmonary, neurological, psychiatric or endocrine diseases, malignancy, or other abnormalities.
Concomitant use of medicines known to prolong the QTc interval, or use of CYP3A4 inducers/inhibitors including but not limited to, carbamazepine, phenytoin, St. John's wort, ciprofloxacin, erythromycin, clarithromycin, fluconazole, ketoconazole, ritonavir or other anti-retroviral medications, fluoroquinolones and clofazamine.
HIV positive, already known or as per HIV test done at screening.
Hepatitis B or C positive
QTc prolongation as per ECG with a QTcF of >450msec or any other significant finding on the ECG as per the investigator
Receipt of any study drug within the past 3 months.
Scheduled to receive any other investigational drug during the course of the study.
Known or suspected, current or history of within the past 2 years, alcohol or drug abuse, that is, in the opinion of the Investigator, sufficient to compromise the safety or cooperation of the volunteer.
Evidence or suspicion of active TB or documented recent (within the last year) household contact with an infectious TB case.
The following toxicities at screening as defined by the DAIDS toxicity table (November 2014)
1. aspartate aminotransferase (AST) grade 3 (≥3.0 x ULN)
2. alanine aminotransferase (ALT) grade 3 (≥3.0 x ULN)