Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia (LICIdystonie)

University Hospital, Lille

Status

Completed

Conditions

Dystonia, Primary

Treatments

Other: LICI

Study type

Interventional

Funder types

Other

Identifiers

NCT03381456

2014-A00244-43 (Other Identifier)

2013_51

Details and patient eligibility

About

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

Enrollment

20 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Patient with hand dystonia : writers cramp
Subject affiliated to social security regimen.

For healthy volunteers :

Healthy volunteer without neurological disorders based on sensorimotor examination.
Subject affiliated to social security regimen.

Exclusion Criteria :

Subject unable to receive informed consent (dementia).
Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).
Patient using a psychotrope treatment.
Patient under guardianship or curatorship.
Pregnant or nursing women.
Patient with a cardiac stimulator.

For healthy volunteers only :

• Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)