Taste Acuity and Caloric Intake After Acute Morphine Administration

Johns Hopkins University

Status: Completed

Conditions: Feeding Behavior; Taste Sweet; Taste Salty

Treatments: Behavioral: taste acuity assessment; Behavioral: Recorded meal

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01763697

K24DA023186-06 (U.S. NIH Grant/Contract)

NA_00046407

Details and patient eligibility

About

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult male and female volunteers
• Ages of 18 to 65

Exclusion criteria

• History of drug dependence (including opioid use disorders)
• History of taste dysfunction
• Significant medical or Axis I psychiatric disorder
• Any trauma or surgical procedures to the head or neck region
• Medication or illicit drug more than 4 out of the last 30 days.
• Pregnancy
• Abnormal electrocardiogram findings
• Negative rating of greater than 40% of the foods available for consumption

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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36 participants in 3 patient groups, including a placebo group

Morhpine/Taste acuity

Active Comparator group

Description:

Taste acuity assessment after 1mg subcutaneous morphine injection

Treatment:

Behavioral: Recorded meal

Behavioral: taste acuity assessment

Placebo/Taste acuity

Placebo Comparator group

Description:

Taste acuity assessment after subcutaneous placebo injection

Treatment:

Behavioral: Recorded meal

Behavioral: taste acuity assessment

Morphine4/Taste acuity

Active Comparator group

Description:

Taste acuity assessment after 4mg subcutaneous morphine injection

Treatment:

Behavioral: Recorded meal

Behavioral: taste acuity assessment