Taste And Smell TEsting in End Stage Renal Disease (TASTE ESRD)

Beth Israel Lahey Health

Status: Withdrawn

Conditions: Olfaction Disorders; Malnutrition; Taste Disorders; Kidney Failure, Chronic

Treatments: Other: Dialysis adequacy; Other: Chronic rhinosinusitis; Other: Worsening of taste from enrollment visit to 6 months; Other: Serum Zinc; Other: Worsening of olfaction from enrollment visit to 6 months; Other: Decayed missing filled teeth index (DMFT)

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03043144

2016P000152

Details and patient eligibility

About

Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status. This study will examine the association between impairment in smell and taste and nutritional and functional markers among patients with end stage renal disease, as well as risk factors for smell and taste impairment.

Full description

People with advanced chronic kidney disease (CKD) are at risk for malnutrition, which is associated with significantly increased mortality. Impairments in olfaction and taste are under-recognized and under-addressed symptoms that affect this population. Olfaction and taste influence appetite and nutritional status and represent a unique target for study and intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general population, but little is known about longitudinal change in olfaction and taste in this population. Additionally, there is a lack of understanding about why these sensory disturbances more commonly occur in people with CKD, although there is speculation that uremia may contribute.

This information gained from this study will address these gaps in knowledge by studying longitudinal changes in olfaction and taste and their associations with concurrent and future nutritional and functional status. Additionally this study will attempt to identify potentially modifiable risk factors associated with olfactory and taste impairment.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 or older
• End-stage renal disease requiring chronic dialysis

Exclusion criteria

• Known allergy to quinine
• Presence of a pacemaker or internal defibrillator
• Pregnancy or breastfeeding

Trial design

0 participants in 1 patient group

End stage renal disease

Description:

Observational study, no intervention

Treatment:

Other: Chronic rhinosinusitis

Other: Worsening of taste from enrollment visit to 6 months

Other: Dialysis adequacy

Other: Decayed missing filled teeth index (DMFT)

Other: Worsening of olfaction from enrollment visit to 6 months

Other: Serum Zinc