Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

University Hospital Basel

Status: Enrolling

Conditions: Obesity

Treatments: Dietary Supplement: Glucose; Dietary Supplement: Quinine; Dietary Supplement: Monosodium glutamate; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02902198

fMRI Taste 2

Details and patient eligibility

About

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Enrollment: 16 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
• right handed

Exclusion criteria

• cardiovascular disease
• neurologic/psychiatric disorders

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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16 participants in 8 patient groups, including a placebo group

Placebo preoperative

Placebo Comparator group

Description:

Single intragastric instillation of 200ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Placebo

Placebo postoperative

Placebo Comparator group

Description:

Single intragastric instillation of 200ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Placebo

Glucose preoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube

Treatment:

Dietary Supplement: Glucose

Glucose postoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube

Treatment:

Dietary Supplement: Glucose

Monosodium glutamate preoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube

Treatment:

Dietary Supplement: Monosodium glutamate

Monosodium glutamate postoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube

Treatment:

Dietary Supplement: Monosodium glutamate

Quinine preoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube

Treatment:

Dietary Supplement: Quinine

Quinine postoperative

Active Comparator group

Description:

Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube

Treatment:

Dietary Supplement: Quinine