Taurine as a Possible Anti-aging Therapy?

University of Sao Paulo

Status: Completed

Conditions: Oxidative Stress

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Taurine

Study type: Interventional

Funder types: Other

Identifiers

NCT05149716

Taurine_aging

Details and patient eligibility

About

Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

Full description

Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation.

Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p < 0.05).

Enrollment: 24 patients

Sex: Female

Ages: 55 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Had being aged 55-70 years;
• Female;
• Post-menopausal;
• Sedentary (not practicing physical exercise for at least 6 months).

Exclusion criteria

• Chronic kidney diseases;
• Infectious contagious diseases;
• Coronary heart disease;
• Smokers
• Alcoholics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups, including a placebo group

Taurine supplementation

Experimental group

Description:

Taurine supplementation composed of capsules of taurine powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks

Treatment:

Dietary Supplement: Taurine

Placebo supplementation

Placebo Comparator group

Description:

Placebo supplementation composed of capsules of starch powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks

Treatment:

Dietary Supplement: Placebo