Taurine in Periodontitis and Aging

Medipol Health Group

Status: Completed

Conditions: Aging; Peridontal Disease

Treatments: Diagnostic Test: Periodontal Indices

Study type: Interventional

Funder types: Other

Identifiers

NCT06635369

1078

Details and patient eligibility

About

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

Enrollment: 66 patients

Sex: All

Ages: 26+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

• ages 18-25 or 45-64
• use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
• presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
• pregnancy or lactation
• alcoholism
• smoking
• nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
• having less than 20 natural teeth, excluding third molars
• use of orthodontic appliances

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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66 participants in 4 patient groups

Young (25-44 years) with a healthy periodontium

Experimental group

Treatment:

Diagnostic Test: Periodontal Indices

young (25-44 years) with Periodontitis

Experimental group

Treatment:

Diagnostic Test: Periodontal Indices

Old (≥65 years) with a healthy periodontium

Experimental group

Treatment:

Diagnostic Test: Periodontal Indices

Old (≥65 years) with Periodontitis

Experimental group

Treatment:

Diagnostic Test: Periodontal Indices