taVNS on Pupillary Response and Perceptual Learning

NYU Langone Health

Status: Enrolling

Conditions: Pupillary Response

Treatments: Procedure: Transcutaneous Auricular Vagal Nerve Stimulation (taVNS); Procedure: Sham Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05386563

22-00516

Details and patient eligibility

About

This study has two parts. The study team will evaluate transcutaneous auricular vagal nerve stimulation (taVNS) and two sham settings during a passive task while measuring pupillary response. Second, the study team will assign either taVNS, sham, or no intervention during a go/no-go task and evaluate perceptual learning over three sessions which will also include measuring the pupillary response and electroencephalogram (EEG).

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy individuals 18 to 65
• Normal audiometric testing

Exclusion criteria

• Co-morbidities including cardiomyopathies, arrhythmias
• Implantable devices including vagal stimulators, pacemakers
• Presence of metallic implants
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 3 patient groups

Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)

Experimental group

Treatment:

Procedure: Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)

Sham

Sham Comparator group

Treatment:

Procedure: Sham Stimulation

No Intervention (Control)

No Intervention group