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taVNS or TMS or Both for Depression

Medical University of South Carolina (MUSC) logo

Medical University of South Carolina (MUSC)

Status

Enrolling

Conditions

Depression

Treatments

Device: Vagus Nerve Stimulation
Device: Transcranial Magnetic Stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT05725239
00125468

Details and patient eligibility

About

The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of the taVNS. The investigators think this combined method might treat depressive symptoms better than either alone. This study is in person at the Institute of Psychiatry in downtown Charleston on the MUSC campus. First, participants will have a screening session and then will have 6 treatment days total where participants will receive either VNS treatment alone, TMS treatment alone, or both at the same time. The treatment that participants start with will be randomized, and they will have 2 treatment days of each combination.

Enrollment

24 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18-75 years old
  • Undergoing cervical VNS or have tried and failed two antidepressant medications in the current episode
  • Able to provide informed consent
  • English speaking and can read and write
  • 17-item Hamilton Depression Rating Scale (HAM-D) score ≥20
  • Not responding to talking therapy.

Exclusion criteria

  • Preexisting neurological disorders, or dementia
  • History of major head trauma
  • Life expectancy <1 year
  • Any type of cognitive impairment that would require approval/signature of a legal guardian/representative for participation
  • A score of >2 on question 3 of the Hamilton Depression Rating pertaining to suicidality
  • Current active suicidal intent or plan, prior attempt within the last 6 months, or who in the judgment of the investigator would be at elevated risk for suicide will be excluded
  • Patients who are pregnant will also be excluded. We will require a pregnancy test for individuals of child-bearing potential.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

24 participants in 3 patient groups

Vagus Nerve Stimulation (VNS) only
Experimental group
Treatment:
Device: Vagus Nerve Stimulation
Transcranial Magnetic Stimulation (TMS) only
Experimental group
Treatment:
Device: Transcranial Magnetic Stimulation
Synchronized VNS and TMS
Experimental group
Treatment:
Device: Transcranial Magnetic Stimulation
Device: Vagus Nerve Stimulation

Trial contacts and locations

1

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Central trial contact

Mark George

Data sourced from clinicaltrials.gov

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