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TCA Cycle in the Dentate in Friedreich's Ataxia

University of Minnesota (UMN) logo

University of Minnesota (UMN)

Status

Completed

Conditions

Friedreich Ataxia

Treatments

Device: MR

Study type

Observational

Funder types

Other

Identifiers

NCT03122925
RAD-2017-25500

Details and patient eligibility

About

OBJECTIVE: To measure the tricarboxylic acid (TCA) cycle rate in the dentate nucleus in a group of control subjects and subjects with Friedreich's Ataxia (FRDA).

HYPOTHESIS: The TCA cycle rate will be lower in FRDA subjects than in controls APPROACH: The investigators will infuse carbon-13 (13C) labeled glucose and measure the rate of 13C label incorporation from glucose to glutamate in the brain using in vivo magnetic resonance spectroscopy.

Full description

The investigators will measure the TCA cycle rate in the dentate nucleus in a group of FRDA patients and in a group of age-matched healthy controls using 13C MRS in vivo together with systemic i.v. infusion of 13C-labeled glucose.

The investigators aim to obtain adequate data in 16 subjects grouped as follows:

  • n=4 pilot subjects (healthy subjects) for testing and optimization of the experimental setup.
  • n=6 healthy controls
  • n=6 FRDA patients

In other to reach this goal, the investigators plan to recruit up to 20 subjects, in case some subjects withdraw before completion of the MR scan, or in case the measured data are not adequate (e.g. technical problem with the scanner).

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18 years of age or older
  • able to consent for themselves
  • considered healthy (controls) OR be diagnosed with FRDA.

Exclusion criteria

  • All subjects:
  • Participants who cannot have an MRI, as determined by the CMRR safety screening form (e.g. metal implant)
  • Pregnancy
  • Clautrophobia
  • Diabetes
  • Clinically significant cardiac disease

Control subjects:

  • Neurological disease

Trial design

20 participants in 2 patient groups

Control
Description:
Healthy subjects
Treatment:
Device: MR
Friedreich's Ataxia
Description:
Diagnosed for Friedreich's Ataxia
Treatment:
Device: MR

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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