tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults Of Working Age (TRAINSTIM1)

Charité University Medicine Berlin

Status: Completed

Conditions: Healthy Older Adults

Treatments: Device: sham-tDCS; Device: tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02794272

TRAINSTIM1.B

Details and patient eligibility

About

The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.

Enrollment: 24 patients

Sex: All

Ages: 50 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• unobtrusive neuropsychological screening
• age: older adults of working age: 50-65 years

Exclusion criteria

• Mild cognitive impairment (MCI) or other neurological diseases.
• History of severe alcoholism or use of drugs.
• Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
• Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 3 patient groups

Anodal tDCS

Experimental group

Description:

Anodal stimulation during resting state fMRI

Treatment:

Device: tDCS

Cathodal tDCS

Experimental group

Description:

Cathodal stimulation during resting state fMRI

Treatment:

Device: tDCS

sham tDCS

Sham Comparator group

Description:

Sham stimulation during resting state fMRI

Treatment:

Device: sham-tDCS