tDCS Effects on GABA Concentration and Brain Functional Connectivity in Young Adults (TRAINSTIM1)

Charité University Medicine Berlin

Status: Completed

Conditions: Healthy Young Adults

Treatments: Device: Transcranial direct current stimulation (tDCS); Device: sham-tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02794298

TRAINSTIM1.C

Details and patient eligibility

About

The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in younger people, compared to sham tDCS.

Enrollment: 32 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• unobtrusive neuropsychological screening
• age: young adults: 18-30 years

Exclusion criteria

• Mild cognitive impairment (MCI) or other neurological diseases
• History of severe alcoholism or use of drugs
• Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems
• Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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32 participants in 3 patient groups

Anodal tDCS

Experimental group

Description:

Anodal stimulation during resting state fMRI

Treatment:

Device: Transcranial direct current stimulation (tDCS)

Cathodal tDCS

Experimental group

Description:

Cathodal stimulation during resting state fMRI

Treatment:

Device: Transcranial direct current stimulation (tDCS)

sham tDCS

Sham Comparator group

Description:

Sham stimulation during resting state fMRI

Treatment:

Device: sham-tDCS