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tDCS-enhanced Working Memory Training in Subjective Cognitive Decline

U

University Hospital Tuebingen

Status

Completed

Conditions

Subjective Cognitive Decline

Treatments

Device: DC-Stimulator MC, NeuroConn

Study type

Interventional

Funder types

Other

Identifiers

NCT03236454
SCDStim-1

Details and patient eligibility

About

This 2-armed randomized, sham-controlled, single-blind study aims at providing evidence for the efficacy of a transcranial direct current stimulation (tDCS)-enhanced cognitive control training (PASAT) in participants with subjective cognitive decline (SCD). Overall, the study will include 30 participants. Each participant will take part in a four weeks training (12 sessions); 50% of the participants will receive 2mA anodal tDCS for 20 minutes applied to the left dorsolateral prefrontal cortex (dlPFC), the other half will receive sham stimulation. Event-related potentials (ERPs) evoked by the feedback on the correctness of the response at baseline and after training will be measured with EEG as neurophysiological signatures of cognitive control. Near and far transfer will be assessed by a verbal 2-back task and the Trail Making Test A and B. The amount of worrying regarding the memory impairment will be quantified by means of a 10 point Likert-Scale. Together with changes of PASAT performance these measures will be obtained before and after the tDCS-enhanced training. Follow-up assessments 3, 12 and 24 months after training will investigate the stability of training effects.

Enrollment

30 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and women, aged 60 years and above Native German speaker Subjective feeling of worsening cognitive abilities, including memory Present concerns regarding the subjective memory decline Right handedness

Exclusion criteria

  • Present objective cognitive impairment (Mini-Mental State Examination < 24)
  • Current depression or depressive episode (Geriatric Depression Scale > 5)
  • Current substance abuse
  • Presence of other psychiatric disorders (MINI International Neuropsychiatric Interview)
  • History of epilepsy
  • Presence of other neurological disorders
  • Absence of independent living skills (Instrumental Activities Of Daily Living, IADL) Scale)
  • Metallic implants near the electrodes (i.e. pacemakers)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

30 participants in 2 patient groups

anodal tDCS
Active Comparator group
Description:
DC-Stimulator MC, NeuroConn: 20 minutes of 2 mA anodal stimulation
Treatment:
Device: DC-Stimulator MC, NeuroConn
sham tDCS
Sham Comparator group
Description:
DC-Stimulator MC, NeuroConn: 20 minutes of sham stimulation; Ramping up over 50 seconds at the beginning and an equal amount of time for tapering off at the end;
Treatment:
Device: DC-Stimulator MC, NeuroConn

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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