tDCS for Laryngeal Dystonia

Yale University

Status: Enrolling

Conditions: Laryngeal Dystonia

Treatments: Device: Starstim system

Study type: Interventional

Funder types: Other

Identifiers

NCT06830174

2000032414

Details and patient eligibility

About

This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).

Full description

Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
• No other known or history of speech, voice disorder other than LD.
• Provision of signed and dated informed consent form.
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Must not be pregnant.

Exclusion criteria

• All individuals who do not meet the above mentioned criteria are excluded from the study.
• Subjects with a history of epilepsy or depression or is claustrophobic.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Laryngeal Dystonia (LD) tDCS

Experimental group

Description:

Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis

Treatment:

Device: Starstim system