Tea Components, Mental Stress and Blood Pressure

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Unilever

Status

Completed

Conditions

Healthy

Treatments

Other: Combination of caffeine and theanine
Other: Caffeine

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02298530
REF-BEV-1803

Details and patient eligibility

About

Assess the effects of adding theanine to a caffeinated beverage on changes in blood pressure during acute mental stress.

Full description

Caffeine and (mental) stress can increase blood pressure. In a typical everyday and/or work environment they commonly coincide. Tea has the reputation of being a relaxing drink. L-theanine is an amino acid found almost exclusively in tea. In a previous study it was shown that caffeine increased blood pressure, while theanine antagonised these effects. In the current study the effect of theanine to a placebo on blood pressure are directly compared.

Enrollment

56 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Apparently healthy males and females
  • Women taking the contraceptive pill
  • 18-45 years of age
  • BMI 20-30 kg/m2
  • Normal or corrected vision
  • Low caffeine consumers (<100mg/day)
  • Non smokers and having been a non-smoker for > 6 months
  • Fluent English
  • Normotensive (>90/60 <140/90 mmHg)

Exclusion criteria

  • Significant current or medical history of cardiovascular disease
  • Low or high STAI trait score in the opinion of the PI
  • Known sensitivity to caffeine or theanine
  • Colour blindness
  • Alcohol consumption above 14/21 units female/male resp. per week
  • Weight loss diet > 10% of bodyweight in the previous year
  • Anyone with a dependency on PI or staff of Department of Epidemiology and Public Health or being an employee of Unilever
  • Reported participation in another biomedical study < 3 months before screening

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Quadruple Blind

56 participants in 2 patient groups, including a placebo group

Combination of caffeine and theanine
Experimental group
Description:
250 mg caffeine + 200 mg theanine
Treatment:
Other: Combination of caffeine and theanine
Caffeine
Placebo Comparator group
Description:
250 mg caffeine
Treatment:
Other: Caffeine

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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