Tear Cytokine Analysis as a Prediction or Diagnostic Marker in Ocular GvHD

Yonsei University

Status: Completed

Conditions: Chronic Graft-versus-host Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02411474

4-2014-0008

Details and patient eligibility

About

Investigate the profiles of tear cytokines in patients who underwent stem cell transplantation (SCT) and attempted to determine the applicability of tear cytokines in the diagnosis of chronic graft-versus-host disease (GVHD). Evaluate tear cytokines as biomarkers of chronic ocular GVHD severity.

Enrollment: 21 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients patients aged 20-60 years who visited the clinic 3-12 months after SCT were included in the study.

Exclusion criteria

• The patients with histories of ocular surgery; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease, as well as patients with long-term use of topical ocular medications except artificial tears.

Trial design

21 participants in 1 patient group

With or without newly diagnosed chronic GVHD after SCT

Description:

The patients developed chronic GVHD after SCT/ The patients did not developed chronic GVHD after SCT