Tear Film SARS-nCoV-2 Detection in Symptomatic and Pauci-symptomatic Patients. (Eye-Covid)

Universitaire Ziekenhuizen KU Leuven

Status: Terminated

Conditions: Covid19; Eye Diseases

Treatments: Diagnostic Test: swabbing of conjunctiva

Study type: Observational

Funder types: Other

Identifiers

NCT04799704

S64002

Details and patient eligibility

About

To investigate the presence of SARS-nCoV-2 in the tear film of symptomatic and pauci-symptomatic SARS-nCoV-2 positive patients.

Full description

The end goal of the study is to show whether or not the virus can be found in the tear film in both symptomatic and less symptomatic patients by means of serial sampling.

A sample of the tears / conjunctiva will be taken with a soft brush (similar to a cotton swab) every three days until the end of the hospitalization. In addition, you must complete a questionnaire that assesses the symptoms present.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject needs to be above 18 years old.
• The subject is willing to undergo sampling of the conjunctiva.
• The subject is willing to fill in a questionnaire.
• The subject is fluent in written and verbal Dutch.
• The subject is capable of giving informed consent.
• Applicable for part 1 only: the subject test positive for SARS-nCoV-2 on a nasopharyngeal swab. The time window between a positive nasopharyngeal swab and the first conjunctival swab may be no more than 3 days.

Exclusion criteria

• Allergy to Oxybuprocainehydrochloride
• Pregnancy or lactation

Trial design

30 participants in 1 patient group

symptomatic patient

Description:

to confirm the detectability of the SARS-nCoV-2 in the tear film of symptomatic patients.

Treatment:

Diagnostic Test: swabbing of conjunctiva