Technical Development of Multi-Parametric Renocerebral MRI

University of Minnesota (UMN)

Status: Enrolling

Conditions: Aging

Treatments: Other: MRI; Other: Group 4

Study type: Observational

Funder types: Other

Identifiers

NCT02831335

1603M85492

Details and patient eligibility

About

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

Enrollment: 120 estimated patients

Sex: All

Ages: 21 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

Exclusion criteria

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

Trial design

120 participants in 4 patient groups

Group 1

Description:

normal 21-35 years old participants

Treatment:

Other: MRI

Other: MRI

Other: MRI

Group 2

Description:

normal 36-50 years old participants

Treatment:

Other: MRI

Other: MRI

Other: MRI

Group 3

Description:

normal 51-65 years old participants

Treatment:

Other: MRI

Other: MRI

Other: MRI

Group 4

Description:

normal 66- 80 years old participants

Treatment:

Other: Group 4