Technical Factors of Embryo Transfer Procedure That Might Affect the Outcome (IAFACT)

Iakentro Fertility Centre

Status: Completed

Conditions: IVF; Pregnancy

Treatments: Device: embryo transfer catheter

Study type: Observational

Funder types: Other

Identifiers

NCT04408547

IakentroFC

Details and patient eligibility

About

Analysis our Embryo transfer data, prospectively collected during the last 6 years (2014- 2019), performed by the same operator YP, who has been doing embryo transfers since 1984. All factors that might impact the embryo transfer will be analyzed. We want to see which factors that influence the success rate are not related to the subjectivity of the operator and could be adjusted through different approaches.

Full description

Most patients undergoing IVF or ICSI reach a blastocyst embryo transfer but less achieve pregnancy and live birth. Many reasons have been proposed to explain these results. Among them, the factor Embryo Transfer Procedure gained less of the attention since few papers have been published and most of them had a lot of biases. In order to eliminate possible biases, we wanted to analyze our Embryo transfer data, prospectively collected during the last 6 years (2014- 2019), performed by the same operator YP, who has been doing embryo transfers since 1984. All factors that might impact the embryo transfer will be analyzed. We want to see which factors that influence the success rate are not related to the subjectivity of the operator and could be adjusted through different approaches.

Primary outcomes: bhCG positive rate, pregnancy rate, ongoing pregnancy rate, live birth rate.

Secondary outcomes: Full bladder, uterine ax orientation, Endometrial thickness, type of catheter, straightforward advancement of the preloaded catheter, use of a stiffer hard catheter to pass through the cervix and the orifice, the site of the uterine cavity that the embryo was released, single or double transfer due to blocked embryo in the catheter.

In addition for each embryo transfer variables that may influence the pregnancy rates will be collected: age of the woman, number of oocytes harvested, sperm characteristics, fertilization rate, stage and grade of the embryos the day of transfer

Enrollment: 3,512 patients

Sex: Female

Ages: 18 to 49 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women undergoing embryo transfer after IVF

Exclusion criteria

• Women with known embryo implantation issues

Trial design

3,512 participants in 2 patient groups

soft catheter

Description:

Patients who underwent embryo transfer with a soft catheter

Treatment:

Device: embryo transfer catheter

stiff catheter

Description:

Patients who underwent embryo transfer with a stiff catheter because soft couldn't pass

Treatment:

Device: embryo transfer catheter