Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study

Ain Shams University

Status and phase: Unknown; Phase 4

Conditions: Anesthesia

Treatments: Drug: Dexmedetomidine; Procedure: Ultrasound guided TAP block; Drug: Fentanyl infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03393988

FMASU R45/2017

Details and patient eligibility

About

This study,will evaluate the efficacy of ultrasound (US)-guided subcostal oblique TAP block together with IV infusion of Dexmedetomidine and fentanyl as a type of multimodal analgesic regimen in comparison with IV fentanyl based analgesia only in live liver donors.

Enrollment: 20 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesia (ASA) physical status I or II
• Scheduled as live liver donors
• J-shaped incision in the supraumblical region

Exclusion criteria

• Patients with a history of psychiatric/neurological illness,
• Hypertensive patients,
• Morbidly obese patients,
• Pregnant and nursing women,
• Patients with known allergic reaction to any of the study medications,
• Patients on recent use of sedatives or analgesics,
• Patients with significant laboratory abnormalities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Group F

Active Comparator group

Description:

Fentanyl infusion (0.5 µg/kg/hr)

Treatment:

Drug: Fentanyl infusion

Group (TAP-Dex)

Active Comparator group

Description:

Ultrasound guided TAP block and Dexmedetomidine * Ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine * Dexmedetomidine infusion(200 µg in 2 ml diluted in 48 ml of saline) * Fentanyl infusion (0.5 µg/kg/hr).

Treatment:

Drug: Fentanyl infusion

Procedure: Ultrasound guided TAP block

Drug: Dexmedetomidine