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Technology and Family Thriving Study (Thrive)

U

University of California, Santa Barbara

Status

Completed

Conditions

Alzheimer Disease
Family Relationship
Mental Health Wellness 1
Quality of Life
Caregiver Burnout
Loneliness
Dementia

Treatments

Behavioral: Video Chat
Behavioral: Virtual Reality

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT05150990
NIH 13336607
3R42AG063640-03S1 (U.S. NIH Grant/Contract)
R42AG063640-02 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this project is to test the impact of different forms of technology (virtual reality vs. video chat) on quality of life and family relationships in older adults who reside in senior living communities and an adult child who lives at a distance. The study will also investigate whether responses to the technology and quality of life outcomes depend on older adults' level of cognitive impairment.

Full description

Purpose of the clinical trial: The virtual reality (VR) program, Rendever, enables older adults in senior living communities to maintain important family relationships, engage fully with life, and reconnect with their past, regardless of physical location, through its advanced networking and live-streaming capabilities. This project will test the immediate and longer-term impact of the Rendever virtual reality platform (vs. video chat) on the quality of life of residents and their adult children in an experimental design. The study will also investigate whether responses to the technology and quality of life outcomes depend on older adults' level of cognitive impairment.

Participants: Participants will be older adults (age 50+) with mild cognitive impairments (MCI) or mild to moderate Alzheimer's Disease or related dementias (ADRD) who reside in senior living communities and an adult child who lives at a distance. The resident-adult child dyads (target N=192 dyads) will be recruited from 12 senior living communities in the greater Boston area and central California. Residents will participate from their senior living community and adult children will participate from their own home, at least 45 minutes driving distance away.

Study Design and Method: The design is a 2 (Intervention Group: Virtual Reality vs. Active Control) x 2 (Level of Cognitive Impairment: MCI vs. ADRD) x Time (7 time points) design. Dyads will be randomly assigned to an intervention group (Virtual Reality vs. Video Chat Control). Dependent variables will include quality of life, psychological and social well-being (loneliness, mental health, thriving, and relationship quality), caregiver guilt (guilt, stress, and burden), and positive engagement while using the technology. Outcomes will be assessed through surveys, interviews, and observational methods.

The experimental intervention will be implemented in a between-group design. Dyads will be randomly assigned to either the Virtual Reality Condition or the active Control Condition (video chat). Participants will complete a baseline survey (T1), followed by four activity sessions once a week for 4 consecutive weeks (T2-T5). Follow-up surveys will be conducted at 1-month (T6) and 3-months (T7) post-intervention for exploratory purposes (to determine if any effects of the technology are sustained over time). Residents and adult children will also be interviewed briefly after the intervention and at each follow-up. All sessions will be video and audiotaped. Computerized and human coding will examine positive engagement and interpersonal dynamics while using the technology.

Dyads assigned to the virtual reality (VR) condition will engage in 4 weekly VR sessions that include immersive virtual adventures (e.g., bucket list travel) and reminiscence activities (e.g., virtual life story). Dyads assigned to the control condition will engage in 4 weekly video chat sessions. During these sessions, dyads will engage in conversations that are typical in their daily lives. All other procedures will be identical in the two conditions.

Sample size, recruitment, and statistical power: A power analysis using simulation methods (for multi-level regression models and structural equation models) was used to determine the sample size. A sample size of 192 dyads (96 in each intervention condition) evenly split between cognitive impairment groups (MCI vs. dementia) will achieve a high level of power for detecting the minimal expected effect size (accounting for expected attrition).

Statistical analysis: Because data from parent-adult child dyads will be dependent, and because the dyad is the unit of analysis for assignment to experimental conditions, the analysis of quantitative data will utilize linear models designed for nested (clustered) data. Hypothesis testing will be conducted with multi-level, random-effects regression and multi-level structural equation modeling.

Study Aims:

AIM 1: Determine whether virtual reality (vs. control) improves quality of life for residents and their adult children who live at a distance.

AIM 2: Determine whether the positive effects of virtual reality (vs. control) on quality of life depend upon residents' level of cognitive impairment (MCI vs. mild to moderate AD/ADRD).

AIM 3: Determine whether virtual reality (vs. control) reduces caregiver guilt for adult children and whether these effects depend on the adult child's own responses to the technology and their parent's responses to the technology.

Enrollment

186 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for older adults:

  • Must reside in one of the senior living communities participating in the study
  • at least 50 years old
  • Fluent in English or Spanish
  • Have MCI or mild to moderate AD/ADRD
  • Mini-mental state examination (MMSE-2) score between 13 and 27
  • Have an adult child who lives at least 45 minutes driving distance from the community and is willing to participate with them
  • Do not have an overly negative, aggressive, or abusive relationship with this adult child

Inclusion Criteria for adult children:

  • At least 18 years old
  • Fluent in English or Spanish,
  • Live at least 45 minutes driving distance from the residential community
  • Do not have an overly negative, aggressive, or abusive relationship with their parent

Exclusion Criteria:

  • Severe AD/ADRD (MMSE-2 score < 13)
  • History of seizure, severe vertigo, hallucinations, or aggression
  • Severe visual impairment (screening will be conducted to determine if vision is sufficient to participate)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

186 participants in 2 patient groups

Virtual Reality
Experimental group
Description:
Weekly activities using virtual reality (Rendever)
Treatment:
Behavioral: Virtual Reality
Video Chat
Active Comparator group
Description:
Weekly activities using video conference (Zoom)
Treatment:
Behavioral: Video Chat

Trial documents
4

Trial contacts and locations

27

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Central trial contact

Nancy Collins, PhD; Tamara Afifi, PhD

Data sourced from clinicaltrials.gov

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