Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity (TEXTOO)

University Hospital, Clermont-Ferrand

Status: Unknown

Conditions: Obese (BMI>90th Percentile); Adolescents (12 to 17 Years Old)

Treatments: Other: Cycling exercises

Study type: Interventional

Funder types: Other

Identifiers

NCT02925572

2016-A00043-48 (Other Identifier)

CHU-0279

Details and patient eligibility

About

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

Full description

40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Enrollment: 40 estimated patients

Sex: All

Ages: 12 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adolescent (12 to 17 years old)
• BMI>90th percentile
• Post puberty (Tanner 3 to 5)
• Inactive (<10 METS/h/week)
• No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity

Exclusion criteria

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Concentric cycling exercise (CON)

Experimental group

Description:

40 obese adolescents will be randomized into 2 groups: CON or EXC

Treatment:

Other: Cycling exercises

eccentric cycling exercise (EXC)

Experimental group

Description:

40 obese adolescents will be randomized into 2 groups: CON or EXC

Treatment:

Other: Cycling exercises