TEG (Thromboelastography) Based Versus Conventional Coagulation Parameters Based Correction of Coagulopathy in Non Variceal Bleed.

Institute of Liver and Biliary Sciences, India

Status: Completed

Conditions: Non Variceal Bleed

Treatments: Biological: Fresh Frozen Plasma; Biological: Platelets Concentrate; Biological: Cryo Precitipitate

Study type: Interventional

Funder types: Other

Identifiers

NCT02689232

ILBS-Variceal Bleed-001

Details and patient eligibility

About

All patients with non variceal bleed who are admitted under the Department of Hepatology at Institute of Liver and Biliary Sciences, who meet the inclusion criteria and who provide informed consent.

Enrollment: 96 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age more than 18
• All patient with Non Variceal bleed (INR>1.8 and platelets<50000)
• Hist logical or imaging proven liver cirrhosis.

Exclusion criteria

1. Variceal Bleed,
2. Pregnancy.,
3. Patients on anticoagulation
4. Patients who refused to participate in the study
5. Post EVL ulcer bleed

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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96 participants in 2 patient groups

Thromboelastography (TEG) level

Experimental group

Treatment:

Biological: Cryo Precitipitate

Biological: Platelets Concentrate

Biological: Fresh Frozen Plasma

Coagulation Profile

Active Comparator group

Treatment:

Biological: Cryo Precitipitate

Biological: Platelets Concentrate

Biological: Fresh Frozen Plasma