Teledermatology and Modulation of Antibiotic Dose in Acne Vulgaris

University of California (UC) Davis

Status: Completed

Conditions: Acne Vulgaris

Treatments: Other: Feedback group; Other: Non Feedback group

Study type: Interventional

Funder types: Other

Identifiers

NCT02905851

869597

Details and patient eligibility

About

To see if teledermatology can be used to reduce antibiotic burden in patients on doxycycline or minocycline for acne vulgaris

Full description

The investigators are going to ascertain if antibiotic burden can be reduced with tele dermatology use.

There are two arms of the study:

1. Feedback group
2. Non feedback group

All subjects will be randomised to either group, all subjects will take photos of their face and answer questions at baseline, visit 2 (1 month), visit 3 (2 months), visit 4 (3 months).

The investigators will then use measurements of acne grading (patient grading, investigator global assessment, lesion counting, global acne grading) to reduce/taper antibiotics in the feedback group.

Enrollment: 4 patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects aged 15 years and older
• Subjects who have been prescribed doxycycline or minocycline by their physician for acne vulgaris but have not initiated treatment yet.

Exclusion criteria

• Subjects who have used isotretinoin in the last 6 weeks
• Those who have used oral antibiotics within the last 4 weeks
• Those who have been initiated or changed brand of oral contraceptive pill within the last one month.
• Those subjects who cannot engage with the teledermatology platform
• Prisoners
• Adults unable to consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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4 participants in 2 patient groups, including a placebo group

Non Feedback

Placebo Comparator group

Description:

No feedback given to this group regarding their antibiotic use Subjects take images and answer questions during the study like the feedback group, but in this group no feedback re dosing is given.

Treatment:

Other: Non Feedback group

Feedback group

Active Comparator group

Description:

Feedback given to this group regarding their antibiotic use after baseline. If the subject is in the feedback group, after this visit, a dermatologist will review all images and the survey results and give the patient information about whether they should: 1. Continue current dose 2. Reduce dose if there is at least a one point improvement in both the investigator acne global assessment AND the patient acne global assessment scores: A dose reduction will be such that the dose is halved from the previous dose. For example if the subject is on minocycline or doxycycline 100 mg twice daily, they will be reduced to minocycline or doxycycline 100 mg daily. 3. Increase dose if had been previously reduced, dose will not be increased beyond the initial starting dose.

Treatment:

Other: Feedback group