Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis

Clalit Health Services

Status: Unknown

Conditions: Primary Sclerosing Cholangitis; Inflammatory Bowel Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02247622

1.1

Details and patient eligibility

About

PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

Full description

Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• informed consent
• documented PSC and inflammatory bowel disease

Exclusion criteria

• under 18 years, above 80 y
• known active malignancy
• decompensated cirrhosis
• patients who cannot sign informed consent

Trial design

60 participants in 3 patient groups

Healthy control

IBD

Description:

patients with inflammatory bowel disease, study group

PSC

Description:

patients with primary sclerosing cholangitis, study group