Temporal Interference for Essential Tremor

Liankun_Ren

Status: Enrolling

Conditions: Essential Tremor

Treatments: Other: Temporal Interference

Study type: Interventional

Funder types: Other

Identifiers

NCT07016425

2024-426-002

Details and patient eligibility

About

This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.

Full description

Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments.

This study aims to investigate the treatment efficacy of TI deep brain stimulation by including essential tremor patients aged 30-70. Before and after TI stimulation, clinical data will be recorded. Clinical and imaging data will be analyzed and processed to advance the treatment of essential tremor.

Enrollment: 10 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 30-70 years old, regardless of gender. Action tremor and postural tremor in both upper limbs, or action tremor and postural tremor in one limb;
• No history of mental diseases;
• Informed consent signed.

Exclusion criteria

• Presence of other neurological diseases affecting the study (such as epilepsy);
• Patients with moderate to severe cognitive impairment (Montreal Cognitive Assessment ≤ 18 points);
• Orthopedic diseases that may affect motor symptoms;
• Patients taking antipsychotic or antidepressant medications;
• Presence of metal implants in the body (such as brain pacemakers or cardiac pacemakers);
• History of electroconvulsive therapy;
• Presence of cardiovascular risk factors, etc.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Temporal Interference

Experimental group

Description:

The investigators perform temporal interference (TI) stimulation to patients with essential tremor. They observe clinical manifestations before and after stimulation to investigate the efficiency of TI.

Treatment:

Other: Temporal Interference