Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults

Taipei Medical University

Status: Enrolling

Conditions: Fallers; Mild Cognitive Impairment

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03839563

NHRI-EX108-10804PI

Details and patient eligibility

About

The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment adults will be compared. Third, whether changes in serum levels of the brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) ε4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.

Enrollment: 189 estimated patients

Sex: All

Ages: 65 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 65 years old
• Had an emergency department visit due to a fall at least 3 months prior to the baseline assessment (assuming a full recovery time from a fall to be 3 months)
• Can ambulate independently
• Has mild cognitive impairment

Exclusion criteria

• Do not live in a community setting
• Cannot ambulate independently and communicate with researchers
• Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia)
• Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

189 participants in 3 patient groups

Conventional exercise

Experimental group

Description:

This exercise will comprise stretching, muscle strengthening, and balance training at increasing difficulty levels, tailored and supervised by a physical therapist, and will take place at a subject's residence or in the neighborhood once a week for 6 months. Each session will last 60 min.

Treatment:

Behavioral: Exercise

Tai chi chuan

Experimental group

Description:

The 8-form Yang-style tai chi chuan intervention will take place at a subject's residence or in the neighborhood once a week for 6 months, and each session will last 60 min.

Treatment:

Behavioral: Exercise

Health education/usual physical activity

No Intervention group

Description:

After the baseline, the case manager will visit subjects in this group once for comparability with the other two intervention groups and instruct them to maintain their usual physical activity.