Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations

Seoul National University

Status: Enrolling

Conditions: Parkinson Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02060695

H-1109-081-378

Details and patient eligibility

About

The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease.

Observational study case-only

Full description

Objectives

1. how many patients will experience motor or nonmotor fluctuation during follow-up period?
2. in how many patients, does motor fluctuation precede nonmotor fluctuation?
3. in how many patients, does nonmotor fluctuation precede motor fluctuation?

Participants: persons with Parkinson disease in early stage who does not have motor or nonmotor fluctuation

Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for each participants

Enrollment: 800 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria
• early stage

Exclusion criteria

• dementia (MMSE<26)
• persons who refuse participating