Teriparatide for Improved Knee Prosthesis Fixation

University Hospital, Linkoeping

Status and phase: Completed; Phase 2

Conditions: Osteoarthritis of the Knee

Treatments: Drug: teriparatide

Study type: Interventional

Funder types: Other

Identifiers

NCT01063504

PTHKnee

Details and patient eligibility

About

The investigators will study how well knee joint prostheses become fixed to the bone when patients get teriparatide, compared to placebo. Measurements will use high resolution 3D radiography (radiostereometry, RSA).

Enrollment: 60 estimated patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Osteoarthritis of the knee planned for prosthesis surgery

Exclusion criteria

• Poor health, drugs affecting bone metabolism.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Teriparatide 20 microgram daily for 2 months

Active Comparator group

Treatment:

Drug: teriparatide

Placebo

Placebo Comparator group

Treatment:

Drug: teriparatide