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Teriparatide for Improved Knee Prosthesis Fixation

U

University Hospital, Linkoeping

Status and phase

Completed
Phase 2

Conditions

Osteoarthritis of the Knee

Treatments

Drug: teriparatide

Study type

Interventional

Funder types

Other

Identifiers

NCT01063504
PTHKnee

Details and patient eligibility

About

The investigators will study how well knee joint prostheses become fixed to the bone when patients get teriparatide, compared to placebo. Measurements will use high resolution 3D radiography (radiostereometry, RSA).

Enrollment

60 estimated patients

Sex

All

Ages

60 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Osteoarthritis of the knee planned for prosthesis surgery

Exclusion criteria

  • Poor health, drugs affecting bone metabolism.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

60 participants in 2 patient groups, including a placebo group

Teriparatide 20 microgram daily for 2 months
Active Comparator group
Treatment:
Drug: teriparatide
Placebo
Placebo Comparator group
Treatment:
Drug: teriparatide

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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