Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage

General Hospital of Northern Theater Command of Chinese People's Liberation Army

Status: Completed

Conditions: Cirrhosis, Liver; Variceal Hemorrhage; Kidney Injury

Treatments: Drug: Octreotide; Drug: Somatostatin; Drug: Terlipressin

Study type: Observational

Funder types: Other

Identifiers

NCT03846180

XHNKKY-VASO 2.0

Details and patient eligibility

About

Terlipressin and somatostatin/octreotide are the first-line choices for the treatment of acute variceal bleeding in liver cirrhosis. Acute kidney injury can develop in patients presenting with acute variceal bleeding. On the other hand, evidence suggests that terlipressin can reverse hepatorenal syndrome. It has been hypothesized that terlipressin can protect the renal function in cirrhotic patients with acute variceal bleeding, except for control of bleeding.

Enrollment: 1,682 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Cirrhotic patients who were admitted between January 2010 and December 2018.
2. A diagnosis of acute gastrointestinal bleeding.
3. Patients who received terlipressin or somatostatin/octreotide.
4. Age or sex was not limited.
5. Use of endoscopy was not limited.
6. Comorbidity was not limited.
7. Malignancy was not limited.

Exclusion criteria

1. Renal parenchymal diseases.
2. Absence of baseline serum creatinine.
3. Absence of serum creatinine 3-5 days after terlipressin or somatostatin/octreotide.
4. Duration of terlipressin or somatostatin/octreotide was less 3 days.
5. Patients who underwent transjugular intrahepatic portosystemic shunt.
6. Patients who underwent surgical shunt, splenectomy with or without devascularization, or liver transplantation.

Trial design

1,682 participants in 2 patient groups

Terlipressin group

Description:

Cirrhotic patients with acute gastrointestinal bleeding received terlipressin with or without somatostatin/octreotide.

Treatment:

Drug: Terlipressin

Somatostatin/Octreotide group

Description:

Cirrhotic patients with acute gastrointestinal bleeding received somatostatin and/or octreotide without terlipressin.

Treatment:

Drug: Somatostatin

Drug: Octreotide