Termination of Persistent Atrial Fibrillation by Catheter Ablation

Shanghai Jiao Tong University

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: Catheter ablation

Study type: Observational

Funder types: Other

Identifiers

NCT04958928

Termination-AF

Details and patient eligibility

About

This is a prospective, multicenter, cohort study aims to demonstrate the role of termination of AF in ablation for persistent atrial fibrillation, and evaluate the clinical outcomes in patients with or without AF termination.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged 18 to 80 years old; 2. Persistent AF; 3. Nonresponse or intolerance to ≥1 antiarrhythmic drug.

Exclusion criteria

1. With uncontrolled congestive heart failure;

2. Having significant valvular disease and/or prosthetic heart valve(s);

3. With myocardial infarction or stroke within 6 months of screening;

4. With Significant congenital heart disease;

5. Ejection fraction was <40% measured by echocardiography;

6. Allergic to contrast media;

7. Contraindication to anticoagulation medications;

8. Severe pulmonary disease e.g. restrictive pulmonary disease, chronic obstructive disease (COPD);

9. Left atrial (LA) thrombus measured by pre-procedure transesophageal echocardiography;

10. Having any contraindication to right or left sided heart catheterization; 11. Previous atrial fibrillation ablation;

11. Presence of an implanted cardioverter-defibrillator; 13. Any cardiac surgery within the past 2 months; 14. Poor general health; 15.Life expectancy less than 6 months.

Trial design

400 participants in 1 patient group

Persistent AF Group

Treatment:

Procedure: Catheter ablation