Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

Universitätsklinikum Hamburg-Eppendorf

Status: Enrolling

Conditions: Parkinson's Disease (PD); Deep Brain Stimulation

Treatments: Device: DBS-coupled tACS

Study type: Interventional

Funder types: Other

Identifiers

NCT07139093

PV7207_1

SCHW 2023/2-1 (Other Grant/Funding Number)

Details and patient eligibility

About

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

Enrollment: 2 estimated patients

Sex: All

Ages: 35 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Provision of written informed consent by the patient
• Age 35 - 85
• patient groups: Parkinson's disease, essential tremor, dystonia
• >3 months after surgery for DBS

Exclusion criteria

• Epilepsy or history of seizures
• Existence of heart pacemaker or other metal implants in the body (except DBS)
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

phase-lags

Experimental group

Description:

Device: phase-lags * DBS will be applied at a fixed frequency between 15-30 Hz in one hemisphere only using the contact(s) of the clinical DBS settings. The amplitude of the electrode in the other hemisphere will be set to 0mA. * tACS will be applied closed-loop at the same frequency as DBS; with 4 phase lags relative to the DBS pulse (0°, 90°, 180°, 270°). tACS will be administered using the neuroConn DC-STIMULATOR PLUS. * EEG will be measured during this intervention with an analog (Digitimer) amplifier.

Treatment:

Device: DBS-coupled tACS