Testing of Innocuousness of Benzalkonium Chloride on the Eye Concerning Possible Growth of Langerhans Cells

University of Rostock

Status and phase: Unknown; Phase 1

Conditions: Eye Diseases

Treatments: Drug: Benzalkonium chloride

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00414739

BAC-2006-1

Details and patient eligibility

About

The study analysis the influence of benzalkonium chloride on the density of antigen presenting Langerhans cells. This is achieved in a double blind randomized study using in-vivo confocal microscopy to identify and quantify Langerhans cells of the human cornea in its central and peripheral part. This study design is based on observations with raised Langerhans cell density after the application of benzalkonium chloride containing eye drops in glaucoma patients.

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy probands

Exclusion criteria

• eye diseases
• pregnancy and lactation period
• drug dependency

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind