Testing Protocol for Cold-sensing Fibers

Aalborg University

Status

Completed

Conditions

Pain

Treatments

Other: Electrical stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT05192577

N-20200014 5-subproject

Details and patient eligibility

About

This project aims to evaluate whether electrical stimulation can modulate the cold detection threshold and the cold pain threshold. The hypothesis is that different electrical stimulation will either decrease or increase the cold threshold depending on the shape of the electrical stimulus. If a combination of electrical stimuli and cold stimuli could be used, this could lead to a novel method for estimating the excitability properties of cold-sensing fibers. The sub-project takes place in 1 session (1.5 hours).

Enrollment

20 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men and women
18-80 years
Speak and understand English

Exclusion criteria

Pregnancy or breast feeding
Drug addiction defined as the use of cannabis, opioids or other drugs
Previous and present neurologic, musculoskeletal or mental illnesses (e.g., epilepsy, neuropathy, fibromyalgia and depression)
Skin diseases
Past history of conditions possibly leading to neuropathy
Inability to cooperate
Current use of medications that may affect the study, e.g., analgesics
Previous traumatic experience of an electrical accident
Consumption of alcohol or painkillers within the last 24 hours
Participation in other pain studies throughout the study period
Patients with cardiac diseases (e.g., pacemaker).