Testing the Effect of Whole-wheat Sourdough Bread Compared to White Bread on Healthy Individuals

Tel Aviv Sourasky Medical Center

Status: Completed

Conditions: Hematologic Tests; Dietary Modification; Bread; Body Weight Changes; Gastrointestinal Microbiome

Treatments: Other: Consumption of white bread; Other: Consumption of sourdough bread

Study type: Interventional

Funder types: Other

Identifiers

NCT02936362

TASMC-12-ZH-658A

Details and patient eligibility

About

Bread is the most common grain product in the world, with consumption surpassing 3 billion individuals per year. Sourdough whole-grain bread is considered a healthy alternative to white, refined-wheat bread.

This cross-over study will test the effect of consumption of sourdough bread compared to white bread following a short dietary intervention period (one week) on multiple clinical parameters and gut microbiota.

Enrollment: 20 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Able to provide and signed informed consent form
• Over 18 years
• Not in active military service
• Ability to technically operate a glucometer

Exclusion criteria

• Prediagnosed type I / type II diabetes mellitus
• Pregnancy
• Usage of antibiotics within three months prior to participation
• Chronically active inflammatory or neoplastic disease in the three years prior to enrollment
• Skin disease, including contact dermatitis, precluding proper attachment of the continuous glucose monitor

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Sourdough bread, white bread

Other group

Description:

Consumption of sourdough bread for one week, 2 week washout, consumption of white bread for one week

Treatment:

Other: Consumption of sourdough bread

Other: Consumption of white bread

White bread, sourdough bread

Other group

Description:

Consumption of white bread for one week, 2 week washout, consumption of sourdough bread for one week

Treatment:

Other: Consumption of sourdough bread

Other: Consumption of white bread