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Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

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University of Pittsburgh

Status

Suspended

Conditions

Depression

Treatments

Behavioral: Cognitive Training
Behavioral: Sham Training

Study type

Interventional

Funder types

Other

Identifiers

NCT05719909
STUDY22090145

Details and patient eligibility

About

In a sample of patients already receiving esketamine treatment as part of their clinical care, this project seeks to test whether we can improve depression by introducing helpful information delivered by a computer-based training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Any patient aged 18-80 in the esketamine clinic in the Center for Interventional Psychiatry. The clinic's extensive screening and eligibility criteria for esketamine treatment will not be altered in any way, other than imposing the study-specific age range and the two exclusion criteria below.

Exclusion criteria

  1. Patients who do not expect to remain located in the Pittsburgh area for a minimum of 1 month beyond study enrollment.
  2. Patients who, in the judgment of the esketamine clinical medical director, show signs of intellectual disability, developmental disability, and/or cognitive impairment (including age-related cognitive decline) of a sufficient degree to interfere with engagement in any study procedure.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

40 participants in 2 patient groups

Cognitive Training
Experimental group
Description:
8 sessions of web-based cognitive training
Treatment:
Behavioral: Cognitive Training
Sham Training
Sham Comparator group
Description:
8 sessions of web-based sham training
Treatment:
Behavioral: Sham Training

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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