Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease

University of Calgary

Status: Completed

Conditions: Chronic Kidney Diseases; Cardiovascular Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT06107166

REB18-0642

Details and patient eligibility

About

Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.

Enrollment: 61 patients

Sex: Female

Ages: 18 to 51 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female sex
• a diagnosis of chronic kidney disease or end stage kidney disease
• age 18-51

Exclusion criteria

Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.