Testosterone Replacement Therapy and Liraglutide Effects on Weight Loss in Hypogonadism.

University Medical Centre Ljubljana

Status and phase: Completed; Phase 4

Conditions: Obesity; Hypogonadism

Treatments: Drug: liraglutide; Drug: Testosterone

Study type: Interventional

Funder types: Other

Identifiers

NCT03619330

TESTOSTERON

Details and patient eligibility

About

The purpose of this study was to compare the effects of liraglutide and testosterone replacement therapy on features of hypogonadism and weight loss in obese men with persistent features of hypogonadism after unsuccessful lifestyle measures.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

liraglutide

Active Comparator group

Description:

In the LIRA group liraglutide was initiated at a dose of 1.2 mg injected sc once per day and increased to 3 mg/day after 1 week.

Treatment:

Drug: liraglutide

testosterone

Active Comparator group

Description:

In the ANDRO group testosterone was initiated at a dose of 50 mg in a gel form once daily.

Treatment:

Drug: Testosterone