TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

Ege University

Status: Completed

Conditions: High Myopia; Gene Mutations

Treatments: Genetic: TGFB1 AND LAMA1 GENE POLYMORPHISMS

Study type: Interventional

Funder types: Other

Identifiers

NCT03451877

2013-TIP-097

Details and patient eligibility

About

The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.

Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

Enrollment: 151 patients

Sex: All

Ages: 3 to 13 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients under the age of 13
• Patients with cycloplegic refraction values ≥6 D (for study group)
• Emmetropic patients (for control group)

Exclusion criteria

• Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease)
• Patients with history of ocular surgery

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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151 participants in 2 patient groups

Study group

Active Comparator group

Description:

Children with cycloplegia refractive error more than -6 D TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined

Treatment:

Genetic: TGFB1 AND LAMA1 GENE POLYMORPHISMS

Control group

Other group

Description:

Emmetropic children TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined

Treatment:

Genetic: TGFB1 AND LAMA1 GENE POLYMORPHISMS