Th17 Inducing Cytokines Pregnancy and After Postpartum

Aydin Adnan Menderes University

Status: Completed

Conditions: Pregnancy

Treatments: Other: Saliva collection; Other: GCF collection

Study type: Observational

Funder types: Other

Identifiers

NCT03449186

BAP-2015

Details and patient eligibility

About

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

Full description

IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Enrollment: 114 patients

Sex: Female

Ages: 19 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women 2 and 3 trimester of their pregnancy

Exclusion criteria

• any known systemic disease,
• periodontal treatment within the last six months,
• patients having less than 10 teeth,
• smokers,
• individuals with a BMI > 30 kg/m2,
• gestational diabetes and preeclampsia during pregnancy.

Trial design

114 participants in 2 patient groups

Pregnancy group

Description:

Women, who were in their second trimester (weeks 16-24) or third trimester (weeks 25-34)selected for the study. Saliva and GCF samples were collected and clinical periodontal measurements were made gently

Treatment:

Other: Saliva collection

Other: GCF collection

Postpartum group

Description:

Postpartum women 6 months after giving birth recalled. Saliva and GCF samples were collected and clinical periodontal measurements were made.

Treatment:

Other: Saliva collection

Other: GCF collection