Thai Prophylactic HIV Vaccine Phase I Study

Kirby Institute

Status and phase

Terminated

Phase 2

Phase 1

Conditions

HIV

Treatments

Biological: pHIS-HIV-AE (DNA vaccine) prime and rFPV-HIV-AE (recombinant fowlpox virus boost) vaccine

Study type

Interventional

Funder types

Other

Identifiers

NCT00333424

NCHECR-AE1

Details and patient eligibility

About

The development of a safe and effective vaccine for HIV is the subject of intensive world-wide research. Various approaches are being investigated in monkey models and humans. This is a randomized, double-blind trial to evaluate the safety and immunogenicity of a candidate preventative human immunodeficiency virus (HIV) vaccine strategy in 24 healthy adult Thai volunteers with no identifiable risk behaviour for HIV-1 infection. Volunteers will receive three "priming" vaccinations at weeks 0, 4 and 8 (pHIS-HIV-AE, a DNA vector delivering AE clade HIV-1 genes). This will be followed at week 12 by single "boost" vaccination (rFPV-HIV-AE, non-replicating, recombinant fowlpox virus vector delivering the same HIV-1 genes). Safety and immunological monitoring will continue to 52 weeks

Enrollment

8 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers, as judged by the screening physician based on medical history, physical examination and laboratory results
18 - 55 years of age, inclusive
Laboratory blood values within clinically acceptable range
Women of reproductive potential must have a negative urine beta-human chorionic gonadotropin (B-HCG) pregnancy test at both the screening and baseline visits
Agreement to employ barrier contraception for 4 weeks preceding entry and for the whole duration of the study (52 weeks)
Agreement to undertake HIV testing and to receive results
Provision of written informed consent approved by the Institutional Ethics Committee (IEC).

Exclusion criteria

HIV positive
HBsAg or HCV positive
Identifiable risk behaviour for HIV infection, defined as any one of the following:
- sexual partners of HIV positive people
- individuals reporting unprotected intercourse with a partner of unknown HIV status, if that partner is reported to be at higher risk for HIV infection ("higher risk of HIV infection" is defined as individuals reporting unprotected anal intercourse (UAI), unprotected intercourse with sex workers and/or sharing injecting equipment within the 12 months preceding trial entry
- men reporting any UAI with male partners of unknown status in the 12 months preceding entry to the study
- individuals who in the 12 months preceding entry to the study have been diagnosed with a new sexually transmissible infection (STI) that may have been acquired through anal or vaginal intercourse (receptive or insertive)
- individuals reporting sharing of injecting equipment in the last 12 months
Recipients of prior HIV candidate vaccines in a previous HIV vaccine trial (does not apply to volunteers who received placebo or adjuvant in such a trial)
Recipients of live attenuated vaccines within 60 days prior to entering the study. Whole killed, toxoid or sub-unit vaccines e.g. influenza, pneumococcus, tetanus, hepatitis B are not exclusionary when given at least 4 weeks prior to the scheduled experimental HIV vaccines
Known or suspected hypersensitivity to egg products or a known history of anaphylaxis or any other serious adverse reactions to any vaccinations
History of serious allergic reactions requiring hospitalisation or emergency medical care (e.g. Steven-Johnson's syndrome, bronchospasm or hypotension) to any substance
Clinically significant intercurrent illness or a history of clinically significant illness requiring immunomodulatory (including corticosteroids) or cytotoxic treatment (e.g. cancer) or any significant disease conditions that in the opinion of the Principal Investigator precludes the individual from participating in the study
Recipients of blood products or immunoglobulins within 6 months prior to entering the study
Recipients of experimental or investigational agents within 30 days prior to entering the study
Recreational and/or therapeutic drug-use that, in the opinion of the Principal Investigator, might compromise the volunteer's participation in any way
Medical or psychiatric condition or occupational responsibilities that may preclude compliance with the protocol
Pregnant or lactating women, or women planning to become pregnant during the trial.