Thalamic Deep Brain Stimulation for Tourette Syndrome

University Hospitals (UH)

Status and phase: Completed; Phase 2

Conditions: Tourette Syndrome

Treatments: Device: Thalamic deep brain stimulation

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00311909

UHC DBS TS

Details and patient eligibility

About

The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 or older
• Diagnosis of Tourette Syndrome by DSM-IV
• Tic frequency at least one per minute at screening
• prior failure of at least two dopamine receptor or presynaptic blockers
• negative impact on quality of life

Exclusion criteria

• significant structural brain lesion (on imaging studies)
• significant dementia
• severe head trauma preceding onset of tics
• use of dopamine receptor blockers prior to recognition of tics
• prior implanted electrical device
• electroconvulsive therapy (ECT) within 24 months
• suicide attempt within 12 months
• significant sociopathic personality
• current or planned pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind